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pentobarbital will lower the level or impact of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Influence of coadministering a robust CYP3A4 inducer with fedratinib hasn't been examined.pentobarbital will lessen the level or effect of tofacitinib by influencing hepatic/intestinal enzyme CYP